ncRNA name | Csp7 siRNA |
ncRNA Category | siRNA |
Disease name | retinitis pigmentosa (RP) |
Species | Mus musculus |
Tissues/Cell_line | mouse photoreceptor cell line 661W |
Methods | siRNA transfection, qRT-PCR, ELISA, ERG |
Expression pattern | associated |
Functional description | The knock-down of caspase-7 in 661W cells expressing T17M RHO leads to a reprogramming of the UPR-associated gene expression and JNK-activated apoptosis. |
PubMed ID | 23470535 |
Year | 2013 |
Title | Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration. |
Drug-related ncRNA | NO |
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